An Australian Company

Co-founded in 1986 by Associate Professor Kerry Bone, MediHerb is the first choice for health care professionals in herbal products in Australia, New Zealand and USA. In October 2004 MediHerb introduced a new synergistic nutritional product range called MH Enhance designed to complement MediHerb’s herbal range.


A key part of MediHerb’s success is that it has over 20 herbalists and naturopaths in various areas of the organisation. These health care professionals, including Kerry Bone, continue to see patients in their own clinics every week so they are in touch with current health issues. This means that we know from our own hands-on experience how the MediHerb products work and can provide health care professionals and their patients with guidance and education. Based in beautiful South-East Queensland, MediHerb’s mission is to provide superior quality, efficacious treatment solutions to health care professionals.

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Total Commitment to Quality

In the words of MediHerb's co-founder, Associate Professor Kerry Bone: “Our passion at MediHerb is to provide the optimum treatment solutions by combining the time-honoured wisdom of traditional knowledge with sound clinical experience and the rigour of scientific research. This quest can only be attained by the total commitment to quality and continuous improvement, which permeates every aspect of our endeavours”.

All MH Enhance products are subject to rigorous testing, ensuring an efficacious product. Several of the products also contain efficacious dosages of MediHerb premium quality herbal ingredients. MH Enhance products deliver synergistic nutrients and quality herbs providing optimal results.


Redefining Quality

MediHerb's commitment to quality is evidenced in every aspect of our business, from the rigorous sourcing and testing of raw materials and the in-depth research and development of herb active constituents and therapeutic applications, to the development of manufacturing and extraction processes that have revolutionised the herbal products industry. In nearly 20 years of operation, MediHerb has not only demonstrated an unwavering commitment to quality in herbal products, we have redefined it. We believe that our unique approach to quality sets a standard for herbal and nutritional products that is unsurpassed in the world today.

Quality Issues with Herbs

Working with herbs to consistently manufacture high quality products is not easy as plants are naturally complex and the quality of a finished product can vary enormously, presenting MediHerb with continual challenges. These challenges are numerous, and include the inherent biological and chemical variability of herbs, the influences on quality of growing, harvesting, drying and storage, extraction of the herb, stability and the ultimate problem of defining quality in a meaningful way.

Not all herbs contain the same levels of active constituents. Not all herbs are grown or harvested or dried or stored in the same way. Not all herb grower's, supplier's, or manufacturer's standards are the same and not all methods to determine quality are the same.

Sourcing of Herbs

FarmersMediHerb is the largest purchaser and processing plant of herbs in Australia and since the beginning we have actively supported Australian and New Zealand herb growers. Our priority is to source herbs from local growers as much as possible and assist with technical support on how best to grow herbs. This support includes information on:

  • Varietal selection
  • Climatic and soil requirements
  • Time of harvest
  • Harvesting techniques
  • Drying parameters
  • Storage requirements post-drying
  • Providing feedback to growers on herb quality

By working with herb growers in this way, we have been able to increase the level of knowledge and awareness of issues affecting herb quality. A comprehensive Herb Grower's Information Kit is available in Australia from MediHerb Customer Service, (call toll-free 1300 265 662 within Australia, or +61 7 46610700 outside Australia. email customerservice@mediherb.com.au).

Wherever possible we aim to source organically grown and wildcrafted herbs, and also work with growers to help cultivate endangered species, for example Golden Seal. We are very fortunate in Australia and New Zealand to have healthy soils and a wonderful climate for herb growing, as a result greater than 40% of the herbs used in the MediHerb products are from local growers. We continue to work with local growers to ensure this proportion is increased in coming years.

We also source herbs from overseas where the climatic conditions and specific handling requirements are the optimum, for example Devil's Claw from the Kalahari Desert and Cat's Claw from Peru. It is particularly important for these indigenous communities who depend on the income of the herb crops for their well-being that they understand the quality issues and how best to grow or sustainably harvest the herb. Together we can ensure that they will sell their crops and provide income for their community.

Our Policy on Endangered and Threatened Medicinal Plants

Arctostaphylos uva-ursiMediHerb takes steps to avoid medicinal plants becoming classified as endangered species and has developed a system of identifying and classifying the 'threat' to particular herbs. 'Threatened' is not an official classification, it is determined by MediHerb based on information received from independent, reliable sources such as CITES (Convention on International Trade in Endangered Species of Wild Fauna and Flora), TRAFFIC (Wildlife Trade Monitoring Network) and United Plant Savers.

When a wildcrafted herb is classified as 'threatened' by MediHerb, steps are taken immediately to find alternatives to overcome or reduce the threat.

Listed below are guidelines MediHerb has developed to reduce the threat of extinction of medicinal plants:

  1. Where the threatened status of a herb is specific to a region or country, MediHerb does not acquire the herb from that region or country, eg Bearberry in parts of South-East Europe
  2. MediHerb uses cultivated herb sources of threatened herbs, where available, eg our Golden Seal is always from a cultivated source
  3. Where no cultivated source is available, MediHerb seeks to establish cultivation in conjunction with herb growers, eg Black Cohosh, False Unicorn Root
  4. If 2 and 3 are not options, MediHerb then investigates the wildcrafting techniques and protocols to ensure they are conducted sustainably and ethically, eg Devil's Claw
  5. In certain cases, substitution of the threatened herb with a medically interchangable species will be possible. This option requires technical and Research & Development involvement, eg Arnica
  6. MediHerb actively promotes using alternate herbs in place of endangered herbs by educating health professionals, eg using Shatavari and Wild Yam rather than False Unicorn (see MediHerb Professional Review No 77)
  7. Where a threatened or endangered herb is part of a tablet or liquid formulation, MediHerb will reformulate the product to include a different herb
  8. When a herb is listed in CITES Appendix II and a cultivated source is not available, MediHerb ceases to use that herb and deletes the product from the range, eg Pygeum

For further information on endangered medicinal plants visit:
www.cites.org
www.traffic.org
www.unitedplantsavers.org

Quality Assurance of Herbs (Identity and Purity)

MediHerb Quality Assured Sourcing of Herbs

Before any herb is purchased, a sample of the batch being offered for sale is analysed by the Quality Control Laboratory and compared to the quality criteria specified by MediHerb. At this point, we regularly reject herbs as only the herbs that meet or exceed the strict quality criteria are purchased.

When we receive the purchased batch of herb, it is sampled according to a statistically valid sampling plan and then subjected to the same battery of tests as the pre-purchase sample. Only if the herb passes this second set of tests is the batch accepted into the factory for further processing.

Depending upon the specific herb, the quality assurance process includes testing herbs for:
  • Colour
  • Aroma
  • Texture
  • Content of specified actives
  • Thin Layer Chromatography fingerprinting
  • Microbial levels
  • Amount of extraneous matter
  • Pesticides and herbicides
  • Heavy metals
  • Aflatoxins
  • Radiation levels
Over the years, we have found many issues relating to quality, for example:
  • Substitution of Scutellaria lateriflora (Skullcap) with other Scutellaria spp.
  • Replacement of Scutellaria lateriflora (Skullcap) with Teucrium spp. (Germander)
  • Adulteration of Hydrastis canadensis (Golden Seal)
  • Centella asiatica (Gotu Kola) substituted for Bacopa monnieri (Bacopa)
  • Substitution of Stephania tetrandra by Aristolochia spp., which has the potential to cause kidney failure
  • Samples of Andrographis paniculata (Andrographis) upon testing at MediHerb, revealed to have no andrographolide content (the active constituent)
  • Samples of Vaccinium myrtillus (Bilberry) upon testing at MediHerb, were found to contain a colouring agent, in order to imitate anthocyanins (the quality marker responsible for the blue colour in ripe Bilberries). Click Here for Bilberry Adulteration Scientific Poster
Our stringent testing regimes guard against:
  • Substitution of species: one herb may be substituted for another less costly herb
  • Adulteration of herbs: a high quality and expensive herb may have a cheaper herb or even a pharmaceutical mixed in with it
  • Poor quality of herbs: herbs can vary enormously in quality and this means the effect you and your patients feel, can vary enormously

This ensures that the herbs approved for use in MediHerb products are of the correct species, are the correct plant part, have the correct active constituent profile and are free from contamination. Therefore you as the clinician can rest assured that the MediHerb product contains exactly what it says on the label.

Substitution – Safety Considerations

Scutellaria lateriflora Substitution of Scutellaria lateriflora (Skullcap) was a prominent issue in 2002 due to an Australian product being implicated in the death of a patient. The product contained Kava and two other herbs, one of these was meant to be Skullcap. However when the product was analysed by the TGA it was found not to contain Skullcap. For this reason the TGA initiated a safety recall on this product and other Skullcap products from that same practitioner company. In addition they also recalled other Skullcap products on the market. This is significant because substitution of Skullcap with the hepatotoxic herb Germander (Teucrium spp.) is well known and has been implicated in cases of liver damage in the literature. MediHerb became aware of this problem many years ago and established stringent quality procedures to ensure that our Skullcap products would always be authentic. In his capacity as a member of TMEC (Traditional Medicines Evaluation Committee) the forerunner of CMEC (Complementary Medicines Evaluation Committee), Kerry Bone alerted the TGA to the potential harm that could arise from this substitution. As a result the TGA took action in the 1990s to ensure that manufacturers only used authentic Skullcap. They conducted widespread testing of Skullcap products and found many products did not contain Skullcap as claimed. The fact that this substitution may have arisen again, particularly in the context of the case of liver damage, is cause for serious concern.

The substitution of Stephania tetrandra with Aristolochia spp. has been widespread in the herbal market with safety alerts being issued by the TGA, FDA (USA) and MHRA (England). This followed the more than 70 cases of renal failure in Belgium associated with a weight-loss product that mistakenly contained a species of Aristolochia instead of Stephania. This inadvertent substitution is believed to have been due to the similarity of the Chinese common name: Aristolochia fangchi (Guang Fang Ji) and Stephania tetrandra (Fang Ji). Stephania is an important herb with good anti-inflammatory activity, linked to the bisbenzylisoquinoline alkaloid known as tetrandrine. MediHerb research evaluated by HPLC eight samples of herb labelled as Stephania tetrandra. Of these samples only one was believed to be Stephania; five samples contained aristolochic acids and were more likely to be Aristolochia; the remaining two samples contained neither aristolochic acids or tetrandrine, and were probably either Clematis spp. or Akebia spp. Based on this survey, the risk involved in the commercially available Stephania herb was evaluated as being too high to warrant its inclusion in the product range.

Substitution – Efficacy

Hydrastis canadensis Through our research we have demonstrated that the alkylamide rich roots of Echinacea angustifolia and to a lesser extent E. purpurea have a modulatory effect on the immune system. However, when market surveillance was performed recently in October 2004 of 8 American professional products of Echinacea tablets and capsules, only one was found to have appropriate levels of alkylamides but even then, the alkylamides were not of the most potent kind (2-ene). Echinacea is broadly used to describe all manner of preparations of the purple cone flower plant: different plant parts and different species, but also different quality levels.

Cat’s Claw (Uncaria tomentosa) has two chemotypes, the preferred chemotype contains only pentacyclic oxindole alkaloids (POAs) speciophylline, mitraphylline, pteropodine, isomitraphylline and isopteropodine; the other chemotype, contains the tetracyclic oxindole alkaloids (TOAs) rhynchophylline and isorhynchophylline in addition to the POAs. Traditionally only the POA chemotype was used therapeutically. This preference for the POA chemotype of Cat’s Claw has been backed up by scientific research. MediHerb tests each batch of Cat’s Claw to determine only the preferred POA chemotype is used to manufacture our Cat’s Claw products.

Golden Seal (Hydrastis canadensis) is very expensive and has always been in short supply. As a result, substitution by other species is common. The herbs typically substituted are: Coptis chinensis, Indian Barberry (Berberis aristata), and Oregon Grape (Berberis aquifolium). These species do not contain hydrastine; they contain only berberine and berberine-related compounds. They do, however, produce an extract of the same colour as Golden Seal. The berberine from Golden Seal and the herbs listed above is a potent antibacterial agent. However, it is the hydrastine that is believed responsible for the unique trophorestorative effects of Golden Seal upon mucous membranes. Similarly, the hair roots of Golden Seal, which have lower levels of hydrastine than the rhizome, are sold as the root and rhizome, which provides lower efficacy. The presence of hydrastine and the differentiation of adulterants is easily determined by HPLC. MediHerb only purchases cultivated Golden Seal, due to the report issued by CITES (Convention on International Trade in Endangered Species of Wild Fauna and Flora) that the herb is endangered in its native habitat. This is a very common example of substitution of a less costly herb which greatly affects efficacy.

Substitution – Cost

Tribulus terrestrisA very common case of substitution is with the herb Tribulus terrestris (Tribulus) due to the very high cost of the raw material. Bulgarian clinical trials utilised a Tribulus extract characterised at 45% furanosterolic saponins by UV-Vis spectrometry, with the plant part being the above ground portion (leaves and stem). Many Chinese and Indian sources typically specify the fruit analysed at 40% by gravimetry – not the accepted plant part nor analytical method. This discrepancy is easily overlooked and the price differential between the two extracts makes the genuine Bulgarian material economically unviable for some patients. MediHerb has extensively investigated Tribulus and in 2002 presented a scientific poster on the comparison of the spectrophotometric and HPLC-ELSD analytical methods, highlighting the variability found in raw herbs of different origins. Click Here to Download Tribulus Scientific Poster. It was shown that only by HPLC could an accurate quantification of the true constituents of the herb be performed. Herbal material from Bulgaria and Slovakia were the only sources found to have the same phytochemical profile as the clinically trialled extract. There was also a significant difference between the phytochemical profile of the fruit (the part used in Asia) compared with the leaves and stems (clinical trials). Only the leaves and stems from Tribulus plants of Bulgaria or Slovakia contain any amount of the active marker compound, protodioscin.

Storage and Handling of Herbs

After approval by the Quality Assurance process, all herbs are transferred to our refrigerated warehouse, which is maintained at a constant 15°C and 40% humidity.

Refrigerated storage, although expensive to maintain, avoids the need for any pesticides to be used for insect control. This ensures our organic herbs remain organic and that all our herbs remain free of insect contamination prior to processing.

Herbs are handled and processed at every stage with the utmost care. For example, herbs are milled in preparation for extraction under very low temperature cryogenic conditions to protect against excessive heating, which can damage the fragile active components.

 

Quality of Extraction

MediHerb was co-founded by Kerry Bone, a first class honours graduate of Melbourne University who won the Masson Memorial Prize as Australia’s top Chemistry student. Whilst working as a research scientist, Kerry studied naturopathy at the Southern School of Natural Therapies for two years before deciding to relocate to the UK to study phytotherapy in-depth.

Upon completing the four-year Diploma in Phytotherapy from the world renowned School of Phytotherapy in England, he returned to Australia to practice. However he became increasingly frustrated with the poor quality of herbal extracts available at that time and the resulting effects for his patients. By applying his scientific training he developed a unique method of extraction, termed 1:2 Cold Percolation. Word of these high quality herbal products spread and requests were soon received from health care professionals for supply around Australia and so MediHerb was born.



Manufacturing Processes

Unique Extraction: Ethanol 1:2 Cold Percolation Process

Silybum marianumThe MediHerb 1:2 Cold Percolation method is unlike other herbal extraction processes; no heat or concentration is used, both of which may cause damage to the delicate plant material. The greatest care is taken to prevent any contamination from outside sources throughout the extraction process:

  • all extraction equipment is designed and built from stainless steel
  • air used in the manufacturing complex is thoroughly cleansed using pharmaceutical standard filtering units

In addition to the herb itself, we use only two other raw materials in manufacturing our herbal extracts, ethanol and purified water. Both are chosen very carefully to ensure the most efficacious product and meet pharmaceutical standard specifications.

All process water used in extraction is purified by reverse osmosis. First, it is filtered through numerous filter beds to remove particulate matter and organic compounds, then passed through reverse osmosis cartridges to remove the ionic materials before finally passing through an ultra-fine filter. The water produced is very low in all contaminants – organic, ionic and particulate – and is tested to comply with the British Pharmacopoeia specification for purified water BP2004.

MediHerb only uses ethanol made from Australian grown grains that complies with the British Pharmacopoeia specification for ethanol, BP2004. Ethanol is essential to extract the full phytochemical profile of the plant, this cannot be achieved using water or glycerol alone. Ethanol has been used for hundreds of years in herbal extraction and old herbal texts discuss steeping herbs in wine over long periods. The human liver is naturally conditioned to metabolise small amounts of ethanol from ripe fruit and naturally fermented food. Any toxic effects from ethanol are dose-related and there is minimal risk of potential ethanol toxicity with herbal extracts due to the low daily dosage required. The usual recommended dose of most 1:2 herbal extracts is only 5 mL three times per day and in 5 mL there is approximately the same amount of ethanol as 1/6 of a standard glass of beer or wine.

Through our scientific analysis MediHerb has chosen specific ethanol percentages for each herb to maximise the quality, for example 25% ethanol extracts of St Mary’s Thistle will not contain any silymarin because it is insoluble at this concentration.

Quality Guaranteed – The MediHerb "Quantified Activity" Program

The MediHerb Quantified Activity (QA) program aims to establish meaningful quality guidelines for the manufacture of herbal extracts. It is a system for ensuring the production of consistent quality extracts with guaranteed minimum levels of active constituents.

To date, MediHerb has quantified the activity of over 70 herbs through this program. To our knowledge such a program has never been undertaken in Australia, nor has it been matched anywhere in the world.

The constituents chosen as ‘quality indicators’ are carefully selected under the guidance of Kerry Bone and represent the most up-to-date scientific knowledge available.

The process of developing Quantified Activity extracts is complex and involves many steps.

However, once the constituents are selected and the quantified activity levels are set, the main focus is to ensure the supply of consistent quality raw material and the retention of the constituents throughout the manufacturing process.

It is important to point out that Quantified Activity extracts are not purified single constituent extracts. They are whole extracts of carefully selected whole herbs, manufactured using the MediHerb 1:2 Cold Percolation process, and still contain the complex range of active constituents from the raw herb.

The Echinacea QA Story

Echinacea purpurea

Echinacea is MediHerb’s earliest quality story and a good example to explain the Quantified Activity program.

When MediHerb first started manufacturing in 1987 there was confusion in the global herbal industry over what constituted authentic Echinacea. Echinacea angustifolia and E. purpurea were routinely being substituted by unsuspecting manufacturers with another herb, Parthenium integrifolium. The substitution was made possible due to the uncanny physical similarity of the roots of Parthenium and especially Echinacea purpurea.

The solution implemented by MediHerb to guarantee supply of authentic Echinacea led to the development of the “Quantified Activity” program which exposed the Parthenium/Echinacea substitution and helped establish MediHerb’s credibility in the herbal industry.

The earliest methods employed by MediHerb to assess herb quality and identity relied on a trained herbalist checking the herb’s physical appearance, colour, odour and taste. Taste was of particular importance because of the insight it gave into the herb’s chemistry.

Traditionally, the test for Echinacea quality was the ability of the root to cause an intense tingling sensation in the mouth when chewed. The substitution of Parthenium integrifolium for Echinacea was successful only if appearance was checked and taste was not. When chewed Parthenium root did not cause any tingling sensation in the mouth. The components which cause the tingling sensation from Echinacea are called alkylamides. So, one very simple solution was to taste the roots!

As MediHerb developed more sophisticated analyses, thin layer chromatography (TLC) was adopted which allowed the gross aspects of Echinacea’s chemistry or its “chemical finger-print” to be compared to a certified reference sample from the correct species. However, TLC mainly demonstrates if a compound is present, but not its quantity.

MediHerb understood that alkylamides were important for the efficacy of Echinacea and began to investigate methods to quantify the alkylamides along with other important compounds such as cichoric acid. At the time there was no published test methodology for alkylamides and the process of developing the high pressure liquid chromatography (HPLC) methodology took MediHerb a number of years.

Once armed with the HPLC methodology for identifying quality in terms of alkylamide content, MediHerb worked with Echinacea growers to determine appropriate growing conditions and handling parameters to ensure optimum retention of the alkylamides. Internally, MediHerb established protocols to ensure optimum retention and stability of alkylamides during all phases of the production process; from receipt of the raw material to completion of the finished product. Alkylamides are very delicate compounds and are easily damaged or lost during processing, hence developing these protocols took many years to conclude.

From these exacting analyses MediHerb was able to establish our standard for acceptance of Echinacea raw material based on alkylamide content. The task then was to work with herb growers to ensure that we were able to consistently source the herb according to our specification. Using our validated 1:2 Cold Percolation process we could then be confident that we would always extract a known amount of alkylamides along with all the other active compounds in every batch. Thus ensuring a consistent quality product with “Quantified Activity”, every batch, every time.

The research into Echinacea continues today and our most recent efforts are aimed at further improving quality and efficacy, and understanding how Echinacea works (Click here for further information on this ground-breaking research).

Quantified Activity and Standardisation

At times, we receive a herb that has higher levels than our minimum specification, so you as the practitioner receive that higher level of activity. We never dilute to meet a minimum specification. Herein lies the difference between Quantified Activity and standardisation. With standardisation, extracts with an active level that exceeds the specified standard would then be diluted to fall within that standard. (For more information on Standardisation see the MediHerb on-line Professional Library.)

With the MediHerb Quantified Activity program, we have linked together all of the possible parameters that can affect product and extract quality and can guarantee that a high quality, efficacious extract will be produced every time.

Quality in Tableting "The MediHerb Way"

Tablet Machine

It’s a different way to make tablets – which is why we call it the MediHerb way. So what do we do that is different?

Firstly and perhaps most importantly, our unique cold percolation 1:2 liquid extracts are used in the manufacture of the MediHerb tablet range which means they are very potent. Many other herbal tablets/capsules are made from powdered dried herbs or poor quality dried extracts which means they are far less potent.

Secondly, our tablet production process has been the focus of extensive research and development to ensure that the finished tablet is as efficacious as the liquid extract, and that the full phytochemical profile has been retained.

From our research, we have found that the optimal method of herb processing involves the evaporation of the ethanol and water at low temperatures under vacuum. This important step minimises the exposure of the delicate chemicals in the herbal matrix to the damaging effects of heat and oxidation. The MediHerb tableting process takes this one step further to actually specify the optimal parameters employed during the evaporation and drying processes for each of the active constituents of the final tablet.

EchinaceaWhile the MediHerb cold percolation 1:2 liquid extracts are used for manufacturing our tablet range, there are on occasion some high quality extracts available from specialist extract manufacturers. In this case, we still apply the MediHerb stringent quality analysis at every step of the purchasing and manufacturing process to ensure our product is of superior quality. For example, there are many St John’s Wort extracts available for purchase but of varying quality, MediHerb would only consider purchasing an extract if it exceeded our quality standards.

As with the MediHerb liquid herbal extracts, our tablets are manufactured to pharmaceutical standards. Each batch of tablets is tested for disintegration, friability, weight uniformity, and where relevant, for active constituents. However, it is only by ongoing research and control of all stages of the manufacturing process from RAW HERB / EXTRACT > LIQUID > TABLET that MediHerb has been able to produce superior tablet formulations, producing tablets with high active constituents that still comply to pharmaceutical standards.

MediHerb tablets must legally disintegrate in less than 30 minutes. This means that even patients with poor digestion can quickly and easily absorb our tablets for maximum efficacy.



Unique Tablet Process

Full Spectrum Extracts Mean Greater Efficacy but Lower Herb Equivalents per Tablet

Scutellaria baicalensisPractitioners often compare herb equivalence on tablet labels in an effort to gauge the most effective formula for their patients. However, herb equivalence can be quite misleading when comparing potency of products.

The process of standardisation can encourage an approach to manufacturing herbal extracts that only focuses on the one active constituent or marker compound whilst ignoring the remaining phytochemical profile of the herb. As we know herbs contain a wide variety of phytochemicals in an inert matrix of vegetable matter (eg cellulose). When a herb is extracted with a solvent, the resulting phytochemicals that are extracted will depend upon the type of solvent employed. Generally the insoluble matrix components will be left behind. By using a combination of solvents, one can very selectively extract an individual compound or one group of compounds. However this begs the question as to whether the process produces a herbal product or a product bordering on a pharmaceutical, because the phytochemical profile of the raw herb and the ratio of active constituents to marker compounds can be greatly altered.

One example of this is the use of Scutellaria baicalensis (Baical Skullcap) extracts, which only contain baicalin and do not contain any of the other 20 or more of its flavonoid constituents. These other constituents are typical of Baical Skullcap, the most important of these being wogonin-7-O-glucuronide, oroxylin A-7-O-glucuronide, baicalein, wogonin and oroxylin A. Sources of Baical Skullcap extract used in some herbal tablets contain greater than 95% baicalin, this means that less than 5% of the material is something other than baicalin. This is no longer a herbal extract and is rather a purified phytochemical (refer to the HPLC trace of Baical Skullcap and baicalin). These extracts are typically claimed to be a 20:1 dry extract and as such 500 mg of this extract placed into a tablet means the manufacturer or marketer of the product would be able to claim (20 x 500 mg) 10,000 mg of Scutellaria baicalensis dry root.

In contrast, the extract produced by extraction of Baical Skullcap with 45% ethanol contains a very high level of solids material and a full complement of the many flavonoid components. As a result, a dry extract made from this liquid can only be manufactured with a 3:1 dry extract concentration factor. Adding 500 mg of this MediHerb extract into a tablet means we can only claim (3 x 500 mg) 1500 mg of Scutellaria baicalensis dry root.

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